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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
13.64
Human Site:
T187
Identified Species:
23.08
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
T187
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Chimpanzee
Pan troglodytes
XP_521839
646
71607
T187
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
P142
H
L
K
L
T
P
A
P
L
K
D
E
M
T
S
Dog
Lupus familis
XP_534051
887
95991
T428
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
D186
F
R
K
L
R
L
F
D
T
P
H
T
P
K
S
Rat
Rattus norvegicus
Q63802
646
71478
T187
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
E146
F
M
S
S
G
R
S
E
K
Q
G
F
D
M
R
Chicken
Gallus gallus
NP_001026352
641
70947
H183
L
R
L
F
D
T
P
H
T
P
K
S
L
L
S
Frog
Xenopus laevis
P47817
555
61670
L128
H
C
R
G
Q
R
L
L
R
F
V
A
G
T
G
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
A174
G
S
T
S
R
R
V
A
L
F
T
N
V
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
K175
S
L
M
A
H
N
K
K
R
C
R
T
Q
F
G
Honey Bee
Apis mellifera
XP_624069
589
66032
P163
Y
Q
N
K
S
D
K
P
T
A
N
V
N
P
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
G182
S
S
T
P
T
D
H
G
D
G
P
I
A
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
L74
L
D
S
D
S
S
E
L
R
N
Q
L
G
S
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
0
100
N.A.
0
100
N.A.
0
6.6
0
6.6
N.A.
0
0
N.A.
0
P-Site Similarity:
100
100
6.6
100
N.A.
6.6
100
N.A.
0
13.3
6.6
6.6
N.A.
13.3
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
8
0
8
0
8
8
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
0
8
8
15
29
8
8
0
8
0
8
8
0
% D
% Glu:
0
0
0
0
0
0
8
8
0
0
0
8
0
0
0
% E
% Phe:
15
0
0
8
0
29
8
0
0
15
0
8
0
15
8
% F
% Gly:
8
0
0
8
8
0
0
8
0
8
8
0
15
0
22
% G
% His:
15
0
0
0
8
0
8
8
0
29
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
29
15
8
0
0
15
8
8
8
8
0
29
8
0
% K
% Leu:
15
15
36
15
29
8
8
15
15
0
0
8
8
8
29
% L
% Met:
0
8
8
0
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
0
8
0
0
8
0
0
0
8
8
8
8
0
0
% N
% Pro:
0
0
0
8
0
8
8
15
29
15
8
29
8
8
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
8
8
0
8
0
0
% Q
% Arg:
29
15
8
29
15
22
0
0
22
0
8
0
0
0
8
% R
% Ser:
15
15
15
15
15
8
8
0
0
0
0
8
0
36
29
% S
% Thr:
0
0
15
0
15
8
0
29
22
0
36
15
0
15
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
8
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _